Public Health

​Dr. Hannah Stocker (MPH)
Netzwerk AlternsfoRschung
Bergheimer Straße 20
69115 Heidelberg

Tel: +49 (0)6221 54 8120
stocker(at)nar.uni-heidelberg.de
Fellows: Prof. Dr. Hermann Brenner

Die Rolle des genetischen Risiko-Scores bei der Erkennung und Prävention der Alzheimer-Krankheit

Die Alzheimer Krankheit ist eine neurodegenerative Krankheit, die 1 von10 älteren Personen im Alter von 65 Jahren und älter betrifft. Die Vererblichkeitvon Alzheimer wurde auf 74% geschätzt. Das ε4-Allel vom Apolipoprotein E ist ein starker genetischer Risikofaktor der Alzheimer Erkrankung. Jedoch sind nur 40 bis 65 Prozent der Alzheimererkrankten ε4 Träger und daher muss es mehrere assoziierte genetische Loci geben. In den letzten Jahren identifizierten große genomweite Assoziationsstudien mindestens 21 zusätzliche genetische Loci, die mit Alzheimer assoziiert wurden, was die Entwicklung des genetischen Risikoscores (GRSs) erhöhte. GRSs rechnen das genetische Risiko unter  Berücksichtigung vieler kleiner Wirkungen verschiedener genetischer Loci. Alzheimer GRSs nutzen Alzheimer assoziierte einzelne Nukleotidpolymorphismen (SNPs) und korrespondierende Assoziationen, um den Risikoscore GRS zu bilden.  Durch die frühe Identifizierung von Personen mit Alzheimerrisiko vor der Manifestation der Erkrankung, haben GRSs das Potential,  zu einer  individualisierten und genauen Alzheimerrisikoprognose beizutragen. Im Rahmen der Dissertation wird ein Alzheimer GRS entwickelt und validiert um die gemeinsame genetische Architektur zwischen der Alzheimer Erkrankung und assoziierten Krankheiten zu erforschen. Das Projekt basiert auf den Daten einer großen prospektiven Kohortenstudie: “ESTHER” (http://esther.dkfz.org/esther/).

Publikationen

2024

• Angelidou, I. A., Stocker, H., Beyreuther, K., & Teichmann, B. (2024). Validation of the “Perceptions Regarding pRE-Symptomatic Alzheimer’s Disease Screening” (PRE-ADS) Questionnaire in the German Population: Attitudes, Motivations, and Barriers to Pre-Symptomatic Dementia Screening. Journal of Alzheimer's Disease, 97(1), 309–325. https://doi.org/10.3233/JAD-230961

2023

• Huemer, M.-T., Kluttig, A., ... Stocker, H., … Thorand, B. (2023). Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - a comparison to the EWGSOP2 cut-off points. Age and Ageing, 52(1). https://doi.org/10.1093/ageing/afac324
• Perna, L., Mons, U., Stocker, H., Beyer, L., Beyreuther, K., Trares, K., Holleczek, B., Schöttker, B., Perneczky, R., Gerwert, K., & Brenner, H. High cholesterol levels change the association of biomarkers of neurodegenerative diseases with dementia risk: Findings from a population-based cohort. Alzheimer's & Dementia, n/a(n/a). https://doi.org/https://doi.org/10.1002/alz.12933
• Stocker, H., Beyer, L., Trares, K., Perna, L., Rujescu, D., Holleczek, B., Beyreuther, K., Gerwert, K., Schöttker, B., & Brenner, H. (2023). Association of Kidney Function With Development of Alzheimer Disease and Other Dementias and Dementia-Related Blood Biomarkers. JAMA Network Open, 6(1), e2252387. https://doi.org/10.1001/jamanetworkopen.2022.52387.

2022

• Giaccherini, M., Farinella, R., ... Stocker, H., ... Campa, D. (2022). Association between a polymorphic variant in the CDKN2B-AS1/ANRIL gene and pancreatic cancer risk. International journal of cancer, 10.1002/ijc.34383. Advance online publication. https://doi.org/10.1002/ijc.34383
• Stocker, H., Beyer, L., Perna, L., Rujescu, D., Holleczek, B., Beyreuther, K., Stockmann, J., Schöttker, B., Gerwert, K., & Brenner, H. (2022). Association of plasma biomarkers, p-tau181, glial fibrillary acidic protein, and neurofilament light, with intermediate and long-term clinical Alzheimer's disease risk: Results from a prospective cohort followed over 17 years. Alzheimer's & dementia : the journal of the Alzheimer's Association, 19(1), 25–35. https://doi.org/10.1002/alz.12614
• Lam, S. Y., Mommersteeg, M. C., ... Stocker, H., Brenner, H., Levy, D., Hwang, S. J., Wood, A. C., Rich, S. S., Rotter, J. I., Taylor, K. D., Tracy, R. P., … Peppelenbosch, M. P. (2022). Toll-Like Receptor 1 Locus Re-examined in a Genome-Wide Association Study Update on Anti-Helicobacter pylori IgG Titers. Gastroenterology, 162(6), 1705–1715. https://doi.org/10.1053/j.gastro.2022.01.011
• Peduzzi, G., Archibugi, L., ... Brenner, H., Vermeulen, R. C. H., Talar-Wojnarowska, R., Vanella, G., Tavano, F., Lucchesi, M., Mohelnikova-Duchonova, B., Chen, X., Kiudelis, V., Hegyi, P., Oliverius, M., Stocker, H., … Campa, D. (2022). Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women. Scientific reports, 12(1), 18100. https://doi.org/10.1038/s41598-022-22973-9
• Trares, K., Bhardwaj, M., Perna, L., Stocker, H., Petrera, A., Hauck, S. M., Beyreuther, K., Brenner, H., & Schöttker, B. (2022). Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study. Alzheimer's research & therapy, 14(1), 128. https://doi.org/10.1186/s13195-022-01063-y
• Beyer, L.*, Stocker, H*., Rujescu, D., Holleczek, B., Stockmann, J., Nabers, A., Brenner, H., & Gerwert, K. (2022). Amyloid-beta misfolding and GFAP predict risk of clinical Alzheimer's disease diagnosis within 17 years. Alzheimer's & dementia : the journal of the Alzheimer's Association, 10.1002/alz.12745. Advance online publication. https://doi.org/10.1002/alz.12745. *Shared first authorship
• Gorski, M., Rasheed, H., Teumer, A., ... Stocker, H.,... Heid, I. M. (2022). Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies. Kidney international, 102(3), 624–639. https://doi.org/10.1016/j.kint.2022.05.021
• Möllers, T., Stocker, H., Perna, L., Rujescu, D., Holleczek, B., Schöttker, B., & Brenner, H. (2022). Subjective short-term memory difficulties at ages 50-75 predict dementia risk in a community-based cohort followed over 17 years. Age and ageing, 51(6), afac113. https://doi.org/10.1093/ageing/afac113
• Nguyen, T. N. M., Chen, L. J., Trares, K., Stocker, H., Holleczek, B., Beyreuther, K., Brenner, H., & Schöttker, B. (2022). Long-term low-dose acetylsalicylic use shows protective potential for the development of both vascular dementia and Alzheimer's disease in patients with coronary heart disease but not in other individuals from the general population: results from two large cohort studies. Alzheimer's research & therapy, 14(1), 75. https://doi.org/10.1186/s13195-022-01017-4
• Lam, S. Y., Mommersteeg, M. C., ... Stocker, H., Brenner, H., Levy, D., Hwang, S. J., Wood, A. C., Rich, S. S., Rotter, J. I., Taylor, K. D., Tracy, R. P., … Peppelenbosch, M. P. (2022). Toll-Like Receptor 1 Locus Re-examined in a Genome-Wide Association Study Update on Anti-Helicobacter pylori IgG Titers. Gastroenterology, 162(6), 1705–1715. https://doi.org/10.1053/j.gastro.2022.01.011
• Gentiluomo, M., Giaccherini, M., Gào, X., Guo, F., Stocker, H., Schöttker, B., Brenner, H., Canzian, F., & Campa, D. (2022). Genome-wide association study of mitochondrial copy number. Human molecular genetics, 31(8), 1346–1355. https://doi.org/10.1093/hmg/ddab341
• Perna, L., Trares, K., Perneczky, R., Tato, M., Stocker, H., Möllers, T., Holleczek, B., Schöttker, B., & Brenner, H. (2022). Risk of Late-Onset Depression and Cognitive Decline: Results From Inflammatory Proteome Analyses in a Prospective Population-Based Cohort Study. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 30(6), 689–700. https://doi.org/10.1016/j.jagp.2021.12.001
• Erhardt, A., Gelbrich, G., Klinger-König, J., Streit, F., Kleineidam, L., Riedel-Heller, S. G., NAKO Investigators (Stocker, H.), Schmidt, B., Schmiedek, F., Wagner, M., Grabe, H. J., Rietschel, M., Berger, K., & Deckert, J. (2022). Generalised anxiety and panic symptoms in the German National Cohort (NAKO). The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 1–16. Advance online publication. https://doi.org/10.1080/15622975.2021.2011409

2021

• Schlosser, P., Tin, A., ... M., Brenner, H., Breteler, M. M. B., Carmeli, C., ... Stocker, H., … Teumer, A. (2021). Meta-analyses identify DNA methylation associated with kidney function and damage. Nature communications, 12(1), 7174. https://doi.org/10.1038/s41467-021-27234-3
• Tin, A., Schlosser, P., Matias-Garcia, P. R., ... Stocker, H., … Köttgen, A. (2021). Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus. Nature communications, 12(1), 7173. https://doi.org/10.1038/s41467-021-27198-4
• Möllers, T., Stocker, H., Perna, L., Nabers, A., Rujescu, D., Hartmann, A. M., Holleczek, B., Schöttker, B., Gerwert, K., & Brenner, H. (2021). Aβ misfolding in blood plasma is inversely associated with body mass index even in middle adulthood. Alzheimer's research & therapy, 13(1), 145. https://doi.org/10.1186/s13195-021-00889-2
• Stocker, H., Nabers, A., Perna, L., Möllers, T., Rujescu, D., Hartmann, A. M., Holleczek, B., Schöttker, B., Stockmann, J., Gerwert, K., & Brenner, H. (2021). Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer's disease. Translational psychiatry, 11(1), 261. https://doi.org/10.1038/s41398-021-01380-0
• Möllers, T., Stocker, H., Perna, L., Nabers, A., Rujescu, D., Hartmann, A. M., Holleczek, B., Schöttker, B., Gerwert, K., & Brenner, H. (2021). Aβ misfolding in blood plasma measured by immuno-infrared-sensor as an age-independent risk marker of Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands), 13(1), e12151. https://doi.org/10.1002/dad2.12151

2020

• Stocker, H., Perna, L., Weigl, K., Möllers, T., Schöttker, B., Thomsen, H., ... & Brenner, H. (2020). Prediction of clinical diagnosis of Alzheimer’s disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years. Molecular psychiatry, 1-11.
• Trares, K., Gào, X., Perna, L., Rujescu, D., Stocker, H., Möllers, T., ... & Schöttker, B. (2020). Associations of urinary 8‐iso‐prostaglandin F2α levels with all‐cause dementia, Alzheimer's disease, and vascular dementia incidence: results from a prospective cohort study. Alzheimer's & Dementia, 16(5), 804-813.
• Möllers, T., Perna, L., Stocker, H., Ihle, P., Schubert, I., Schöttker, B., ... & Brenner, H. (2020). New use of psychotropic medication after hospitalization among people with dementia. International journal of geriatric psychiatry, 35(6), 640-649.

2019

• Möllers, T., Stocker, H., Wei, W., Perna, L., & Brenner, H. (2019). Length of hospital stay and dementia: a systematic review of observational studies. International journal of geriatric psychiatry, 34(1), 8-21.
• Stocker, H., Nabers, A., Perna, L., Möllers, T., Rujescu, D., Hartmann, A., ... & Brenner, H. (2019). Prediction of Alzheimer's disease diagnosis within 14 years through Aβ misfolding in blood plasma compared to APOE4 status, and other risk factors. Alzheimer's & Dementia.
   

Kurzlebenslauf

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