Pharmacy

Thi Ngoc Mai Nguyen, Pharmacist
Netzwerk AlternsfoRschung (NAR)
Bergheimer Straße 20
D-69115 Heidelberg

Phone: +49 (0)6221 54 8143
nguyen(at)nar.uni-heidelberg.de
Fellow: Ben Schöttker, PhD

 

Analgesics utilisation in the older German population and implications for gastrointestinal ulcers, renal function, and cardiovascular events

Pain is one of the most common reasons for seeking medical care, and non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely used group of analgesics. One out of four adults aged 65 years or older are prescribed NSAIDs (including aspirin in a low, cardiovascular protective dose) in the general practice setting. However, NSAIDs are also known to be have several adverse effects and are listed under certain conditions as potentially inappropriate drugs (PIM) for adults aged 65 years and older. Several PIM lists are available, but they differ strongly in listed NSAIDs. Recommendations under which conditions these NSAIDs could be indicated and thus should not be considered as PIMs also vary. One part of my research will be to compare the criteria of the different PIM lists with a focus on NSAIDs, and to assess the PIM prevalences of the different PIM lists among NSAIDs users in the ESTHER study - a population-based cohort study from Germany.

Although the associations between use of NSAIDs and gastroduodenal ulcers, cardiovascular events and renal function decline have been well-established in clinical trials, there is still need to re-evaluate these associations for multi-morbid older adults because these patients, who use the most analgesics in the real world, were often excluded from these clinical trials. Therefore, I aim to re-evaluate the strengths of these associations with real-world data from older adults included in the observational ESTHER and KAROLA study.

 

Publications

  • Nguyen, T., Laetsch, D. C., Chen, L. J., Holleczek, B., Meid, A. D., Brenner, H., & Schöttker, B. (2021). Comparison of Five Lists to Identify Potentially Inappropriate Use of Non-Steroidal Anti-Inflammatory Drugs in Older Adults. Pain medicine (Malden, Mass.), pnaa480. Advance online publication. https://doi.org/10.1093/pm/pnaa480
  • Nguyen TNM, Laetsch DC, Chen LJ, Holleczek B, Meid AD, Brenner H, Schöttker B. Comparison of Five Lists to Identify Potentially Inappropriate Use of Non-Steroidal Anti-inflammatory Drugs in Older Adults. Pain Med. 2021 [epub ahead of print]
  • Nguyen TNM, Laetsch DC, Chen LJ, Haefeli WE, Meid AD, Brenner H, Schöttker B. Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany. Eur J Clin Pharmacol. 2020;76(12):1695-1707
  • Chen LJ, Trares K, Laetsch DC, Nguyen TNM, Brenner H, Schöttker B. Systematic review and meta-analysis on the associations of polypharmacy and potentially inappropriate medication with adverse outcomes in older cancer patients. J Gerontol A Biol Sci Med Sci. 2020 [Epub ahead of print].

 

Vita

Since 02/2019 PhD Student, Network Aging Research (NAR), University of Heidelberg
2016-2018 Master of Public Health, University of Tsukuba, Japan
2015-2016 Pharmacist, University Medical Center, Ho Chi Minh, Vietnam
2010-2015 Studies of Pharmacy, University of Medicine and Pharmacy, Ho Chi Minh, Vietnam

 

 

 

 

 

kutsubinas: Email
Latest Revision: 2021-07-15
zum Seitenanfang/up