Epidemiologie

Tobias Möllers - Epidemiologist M.Sc.
Network Aging Research
Bergheimer Straße 20
D-69115 Heidelberg

Tel: +49 (0)6221 54 8125
moellers(at)nar.uni-heidelberg.de

Fellows: Prof. Dr. Hermann Brenner

Hospitalisations of People with Dementia: Epidemiologic Analyses based on Health Insurance Data

In the process of demographic ageing the proportion of people with dementia will rise, especially among people treated in acute care hospitals. Hospitalisations of people with dementia are accompanied by higher complications- and mortality rates, a higher risk for institutionalisation after discharge and a prolonged length of stay.  Neurobehavioral and neuropsychiatric symptoms of dementia represent a great challenge for hospitals and their employees. For the best possible planning and improvement of care, epidemiologic data on indications, determinants, frequencies, duration and outcome of hospitalisations are necessary. Such data is limited, particularly in Germany. Within this dissertation the following research questions are dealt with:

• Frequency, duration, indication and temporal sequence of hospitalisations
• Possible determinants of the abovementioned outcomes
• Changes in the dementia specific- and co-medication
• Mortality during and after hospitalisations

Publications

• Möllers, T., Perna, L., Stocker, H., Ihle, P., Schubert, I., Schöttker, B., Frölich, L., & Brenner, H. (2020). New use of psychotropic medication after hospitalization among people with dementia. International Journal of Geriatric Psychiatry, 35(6), 640–649. https://doi.org/10.1002/gps.5282.
• Stocker, H., Nabers, A., Perna, L., Möllers, T., Rujescu, D., Hartmann, A., Holleczek, B., Schöttker, B., Gerwert, K., & Brenner, H. (2020). Prediction of Alzheimer's disease diagnosis within 14 years through Aβ misfolding in blood plasma compared to APOE4 status, and other risk factors. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 16(2), 283–291. https://doi.org/10.1016/j.jalz.2019.08.189.
• Stocker, H., Perna, L., Weigl, K., Möllers, T., Schöttker, B., Thomsen, H., Holleczek, B., Rujescu, D., & Brenner, H. (2020). Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years. Molecular Psychiatry. Advance online publication. https://doi.org/10.1038/s41380-020-0764-y.
• Trares, K., Gào, X., Perna, L., Rujescu, D., Stocker, H., Möllers, T., Beyreuther, K., Brenner, H., & Schöttker, B. (2020). Associations of urinary 8-iso-prostaglandin F(2α) levels with all-cause dementia, Alzheimer's disease, and vascular dementia incidence: Results from a prospective cohort study. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 16(5), 804–813. https://doi.org/10.1002/alz.12081.
• Möllers, T., Perna, L., Stocker, H., Ihle, P., Schubert, I., Schöttker, B., Frölich, L., Bauer, J., & Brenner, H. (2019). Alzheimer's disease medication and outcomes of hospitalisation among patients with dementia. Epidemiology and Psychiatric Sciences, 29, e73. https://doi.org/10.1017/S2045796019000702.
• Möllers, T., Perna, L., Ihle, P., Schubert, I., Bauer, J., & Brenner, H. (2019). Factors Associated with Length of Stay in Hospital Patients with and Without Dementia. Journal of Alzheimer's Disease: JAD, 67(3), 1055–1065. https://doi.org/10.3233/JAD-180593.
• Möllers, T., Stocker, H., Wei, W., Perna, L., & Brenner, H. (2019 Jan). Length of hospital stay and dementia: A systematic review of observational studies. England. https://doi.org/10.1002/gps.4993.
• Muellmann, S., Forberger, S., Möllers, T., Bröring, E., Zeeb, H., & Pischke, C. R. (2018 Mar). Effectiveness of eHealth interventions for the promotion of physical activity in older adults: A systematic review. United States. https://doi.org/10.1016/j.ypmed.2017.12.026.
• Stocker, H., Möllers, T., Perna, L., & Brenner, H. (2018 Aug 24). The genetic risk of Alzheimer's disease beyond APOE ε4: Systematic review of Alzheimer's genetic risk scores. https://doi.org/10.1038/s41398-018-0221-8.
• Kebede, M., Steenbock, B., Helmer, S. M., Sill, J., Möllers, T., & Pischke, C. R. (2018). Identifying Evidence-Informed Physical Activity Apps: Content Analysis. JMIR MHealth and UHealth, 6(12), e10314. https://doi.org/10.2196/10314.
• Kebede, M. M., Liedtke, T. P., Möllers, T., & Pischke, C. R. (2017). Characterizing Active Ingredients of eHealth Interventions Targeting Persons with Poorly Controlled Type 2 Diabetes Mellitus Using the Behavior Change Techniques Taxonomy: Scoping Review. Journal of Medical Internet Research, 19(10), e348. https://doi.org/10.2196/jmir.7135.

Vita